With Mounjaro being available in the Netherlands, it’s important to understand the differences between these medications. Both are administered via injection pens but contain different active ingredients. As the number of weight-loss medications on the market grows, it’s essential to examine these differences. This article explores the distinctions between Wegovy and Mounjaro.
Ozempic and Wegovy
Ozempic is a well-known weight-loss medication, similar to Wegovy, as both contain the active ingredient semaglutide. This substance mimics a hormone that suppresses appetite. GLP-1 receptor agonists, such as semaglutide, increase insulin secretion by slowing stomach emptying and inhibiting the production of glucagon, another hormone involved in blood sugar regulation. This results in lower blood sugar levels.
Active Ingredients in Mounjaro
Mounjaro, which contains the active ingredient tirzepatide, is approved for the treatment of type 2 diabetes and is also used off-label for obesity. According to a study by Eli Lilly (the drug’s manufacturer), tirzepatide leads to a weight loss of up to 21.4%. Mounjaro not only includes a GLP-1 receptor agonist but also a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. GIP is a hormone produced in the gut in response to food intake, especially carbohydrates and fats. GIP helps regulate blood sugar levels and metabolism through various mechanisms, including:
- Insulin Secretion: GIP stimulates insulin release from the pancreas when glucose is present in the blood, helping cells absorb glucose and lower blood sugar levels.
- Glucagon Production: GIP can also reduce glucagon production. Glucagon prompts the liver to produce and release glucose, raising blood sugar levels. By decreasing glucagon production, GIP helps indirectly lower blood sugar levels.
- Fat Metabolism: GIP influences fat metabolism by promoting fat storage in fat cells.
- Appetite and Satiety: GIP may affect appetite and feelings of fullness, though this effect is less pronounced compared to other gut hormones like GLP-1.
Similarities and Differences
Ozempic and Wegovy are both semaglutide-based medications that mimic the action of the GLP-1 hormone. All three medications are administered via weekly injections, starting with a low dose that can be increased over time. Their side effects also overlap, including nausea, vomiting, or diarrhea.
However, while Ozempic and Wegovy only replicate the effects of GLP-1, Mounjaro mimics both GLP-1 and GIP. It is advisable to consult with a healthcare professional to determine which medication is best suited to your needs.
Source: Forbes Health
